Geriatric Medication Safety: How to Protect Elderly Patients from Harmful Drugs
  • Dec, 4 2025
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Every year, more than 1 in 3 hospital admissions for people over 65 are caused by medication problems. Not because they didn’t take their pills, but because the pills they were given were the wrong ones - or too many of them. This isn’t a rare mistake. It’s a systemic issue built into how we treat older adults. The truth is, what works for a 40-year-old can be dangerous for an 80-year-old. And yet, many doctors still prescribe the same drugs the same way.

Why Older Adults Are at Higher Risk

As we age, our bodies change. Kidneys slow down. Liver function declines. Fat replaces muscle. These changes mean drugs stay in the system longer, build up to toxic levels, and interact in unpredictable ways. A single dose of a sleeping pill that’s fine for a 50-year-old can send an 80-year-old into confusion, falls, or even coma. That’s not an accident - it’s predictable.

On top of that, most older adults take multiple medications. The average person over 65 is on five prescriptions. One in four takes ten or more. This is called polypharmacy. And it’s not always necessary. Many of these drugs were prescribed years ago for conditions that have since changed or disappeared. But no one ever stopped them.

Studies show that when older adults are given potentially inappropriate medications (PIMs), their risk of hospitalization jumps by 91%. They’re 60% more likely to lose mobility. And they’re 26% more likely to have a dangerous reaction - even if they’ve taken the same drug for years. The more PIMs they get, the worse it gets. Each extra one adds risk, not benefit.

The Beers Criteria: The Gold Standard for Safe Prescribing

In 1991, the American Geriatrics Society created a simple tool to help doctors avoid these mistakes. It’s called the Beers Criteria. Today, it’s the most cited guide in geriatric medicine, with over 1,200 research papers referencing it. The latest version, updated in 2023, lists 139 drugs or drug classes that should generally be avoided in older adults.

These aren’t random guesses. Each one is backed by clinical data. For example, benzodiazepines like diazepam and lorazepam - once common for anxiety or sleep - are now flagged because they cause dizziness, falls, and memory loss in seniors. Anticholinergics, used for overactive bladder or allergies, are linked to dementia risk. NSAIDs like indomethacin and ketorolac can cause kidney failure or stomach bleeds in older patients. Even aspirin, long thought to prevent heart attacks, is now restricted for primary prevention in people over 70 because bleeding risks outweigh benefits.

Some updates are specific. Tramadol, once considered safe for pain, is now listed because it can trigger dangerously low sodium levels - especially when mixed with diuretics or antidepressants. That’s not a side effect. It’s a known, measurable danger. And it’s preventable.

What makes the Beers Criteria powerful isn’t just the list - it’s how widely it’s used. Epic, the biggest electronic health record system in the U.S., now triggers automatic alerts for these drugs in 87% of its geriatric installations. When a doctor tries to prescribe a flagged medication to a 75-year-old, the system pops up a warning. That’s a big step forward.

Split image: elderly man overwhelmed by pills on one side, practicing safe alternatives on the other.

The Missing Piece: What to Use Instead

But here’s the problem. Telling doctors what not to prescribe isn’t enough. Many don’t know what to prescribe instead. That’s why, in July 2025, the American Geriatrics Society released something new: the Beers Criteria Alternatives List.

This isn’t just a list of safer drugs. It’s a practical guide to non-drug options too. For example, instead of giving a sleeping pill for insomnia, the Alternatives List suggests cognitive behavioral therapy for insomnia (CBT-I) - a proven, long-lasting fix that doesn’t cause falls. For chronic pain, it recommends physical therapy, heat, or acupuncture before reaching for opioids. For urinary incontinence, pelvic floor exercises beat anticholinergics every time.

Out of 47 recommended alternatives, nearly 40% are non-pharmacological. That’s a game-changer. For years, doctors felt stuck - they knew a drug was risky, but had no clear alternative. Now, they have options. And those options are backed by real evidence, not guesswork.

How Hospitals Are Making It Work

Some places are turning this knowledge into real results. At the Mayo Clinic Rochester emergency department, a team of pharmacists, geriatricians, and ED doctors worked together for six months to redesign how medications are handed out. They trained staff, rewrote protocols, and added pharmacist-led medication reviews before discharge. Within six months, they cut potentially inappropriate prescriptions by 38%.

At the University of Alabama at Birmingham, they focused on medication reconciliation - going through every drug a patient was taking before admission and deciding what to keep, stop, or change. Their 30-day readmission rate for medication-related problems dropped by 22%.

These programs didn’t happen by accident. They required training, time, and resources. Most successful teams include at least one clinical pharmacist with geriatric certification. They spend about 0.5 full-time equivalent per 20,000 emergency visits. That’s not expensive compared to the cost of a single hospital readmission, which averages $12,000.

But not every hospital has the staff. Rural EDs, in particular, struggle. Only 31% have full geriatric medication safety programs, according to the National Rural Health Association. And even where systems exist, alert fatigue is a problem. In one survey, 65% of doctors ignored Beers Criteria warnings because the system flagged everything - even safe drugs like warfarin for atrial fibrillation. That’s why the AGS is working on AI-driven alerts that understand context, not just age.

Medical team reviewing medication list on tablet, replacing dangerous drugs with non-pharmacological options.

What Patients and Families Can Do

You don’t have to wait for the hospital to fix this. If you or a loved one is over 65 and taking multiple medications, ask these questions:

  • Why am I taking this drug? Is it still needed?
  • Is there a non-drug option I could try first?
  • Could this interact with my other meds or health conditions?
  • What happens if I stop it? What if I keep taking it?

Bring a full list of everything you take - including over-the-counter pills, supplements, and creams - to every appointment. Ask for a medication review at least once a year. If your doctor doesn’t know the Beers Criteria, ask them to look it up. It’s free and publicly available.

Don’t assume that if a drug was prescribed years ago, it’s still right. Bodies change. Conditions change. So should your meds.

The Bigger Picture: Why This Matters Now

By 2030, 21% of the U.S. population will be over 65. That’s 74 million people. And 1 in 3 of them will be hospitalized because of a medication problem. The cost? $528 billion a year. That’s not just money. It’s lost independence, broken hips, cognitive decline, and early death.

Medicare and Medicaid are starting to act. CMS now requires emergency departments to track medication safety under Measure 238. Hospitals that fail to meet standards face reimbursement cuts. That’s pushing change.

But real progress won’t come from rules alone. It comes from doctors who listen. Pharmacists who ask questions. Families who speak up. And systems that don’t just warn - but guide.

The tools exist. The evidence is clear. The question isn’t whether we can do better. It’s whether we will.

What are the most dangerous drugs for elderly patients?

The most dangerous drugs for older adults include benzodiazepines (like diazepam), anticholinergics (like diphenhydramine), NSAIDs (like ketorolac), and certain opioids (like meperidine). The 2023 Beers Criteria also added tramadol due to its risk of causing low sodium levels, and restricted aspirin for primary heart disease prevention in people over 70. These drugs increase fall risk, confusion, kidney damage, and bleeding. Many are still prescribed routinely, even though safer alternatives exist.

Can elderly patients stop taking medications safely?

Yes - but only under medical supervision. Stopping a drug suddenly can be dangerous, especially for antidepressants, blood pressure meds, or seizure medications. The key is deprescribing: a planned, gradual reduction based on the patient’s goals, health status, and risk factors. The AGS Alternatives List provides guidance on how to safely stop certain drugs and what to replace them with. A clinical pharmacist or geriatrician should lead this process.

What’s the difference between Beers Criteria and STOPP/START?

The Beers Criteria focus on identifying potentially inappropriate medications (PIMs) to avoid. STOPP/START does both: it flags inappropriate prescriptions (STOPP) and also identifies important medications that are being missed (START). For example, STOPP might flag a benzodiazepine, while START might remind the doctor that the patient needs a statin for heart disease. Together, they give a fuller picture of prescribing quality.

How do I know if my elderly parent is on too many drugs?

Signs include confusion, dizziness, falls, memory problems, constipation, or sudden fatigue after starting a new drug. If your parent takes five or more prescriptions, especially if they’ve been prescribed by different doctors, it’s time for a medication review. Ask for a pharmacist-led assessment. Bring all pills - including vitamins and OTC meds - to the appointment. Don’t assume everything is still necessary.

Are there non-drug options for common elderly conditions?

Yes, and they’re often more effective. For insomnia, try cognitive behavioral therapy (CBT-I). For chronic pain, physical therapy, heat, or acupuncture work better than opioids. For overactive bladder, pelvic floor exercises reduce symptoms without side effects. For anxiety, regular walking or mindfulness training can be as good as benzodiazepines. The AGS Alternatives List includes 47 evidence-backed non-drug options. These aren’t just ‘nice to have’ - they’re first-line recommendations.

Graham Holborn

Graham Holborn

Hi, I'm Caspian Osterholm, a pharmaceutical expert with a passion for writing about medication and diseases. Through years of experience in the industry, I've developed a comprehensive understanding of various medications and their impact on health. I enjoy researching and sharing my knowledge with others, aiming to inform and educate people on the importance of pharmaceuticals in managing and treating different health conditions. My ultimate goal is to help people make informed decisions about their health and well-being.

14 Comments

Isabelle Bujold

Isabelle Bujold

4 December 2025

It’s wild how often we treat elderly patients like they’re just smaller versions of middle-aged adults. I’ve seen geriatric pharmacists spend 45 minutes just untangling a med list that’s been piling up since 2008 - half those pills were for conditions that resolved a decade ago. The Beers Criteria isn’t just a list, it’s a lifeline. And the Alternatives List? That’s the real breakthrough. Non-pharm options like CBT-I for insomnia or pelvic floor therapy for incontinence aren’t ‘alternative’ - they’re first-line. We just forgot to teach that in med school. The fact that 40% of the new recommendations are non-drug is a quiet revolution. It’s not about removing meds, it’s about restoring function. And honestly, if your grandma can sleep better without benzos or stop peeing her pants without anticholinergics, why are we still prescribing the risky stuff? It’s not just safer - it’s more human.

And don’t get me started on how hospitals still don’t have geriatric pharmacists on rounds. You wouldn’t let a cardiologist prescribe insulin without an endocrinologist’s input. Why are we letting primary care throw five new scripts at a 78-year-old with three specialists and no one coordinating? It’s not negligence - it’s systemic laziness. We need mandatory geriatric med reviews at every hospital discharge. Period.

Also, the AI-driven alert systems? Long overdue. Right now, the EHR screams ‘DANGER’ for everything from warfarin to aspirin, so doctors just click past it. Context matters. A 72-year-old with atrial fibrillation needs warfarin. A 72-year-old with no history of heart disease doesn’t need aspirin. The system should know that. We’re not asking for magic - just basic logic.

I’ve watched my mom’s meds get trimmed down from 14 to 6 over six months. Her balance improved. Her confusion cleared. She started gardening again. That’s not a miracle. That’s good medicine. And it’s available. We just have to demand it.

Stop calling it ‘deprescribing.’ Call it ‘right-sizing.’ We’re not taking away care. We’re giving back dignity.

Also - bring the pill bottle. Every. Single. Time. Not a list. The actual bottles. I’ve seen people forget they’re taking melatonin, then get prescribed another sleep aid. It’s like bringing a grocery list to the fridge and forgetting you already have milk.

And yes, I’m a pharmacist. And yes, I’m still mad about this.

But I’m also hopeful. We’re getting there.

Rachel Bonaparte

Rachel Bonaparte

5 December 2025

Oh sweetie, you’re so cute thinking this is just about ‘medication safety.’ This is the pharmaceutical-industrial complex slowly strangling our elders to keep profits rolling. Benzodiazepines? Big Pharma pushed them for decades. NSAIDs? Designed to be addictive in their side effects - so you keep refilling. And now they slap a ‘Beers Criteria’ sticker on it like it’s a new idea? Please. The FDA approved 80% of these drugs before anyone knew what a geriatric kidney even looked like. And now they want you to believe the system is ‘fixing’ itself? The same system that lets drug reps hand out free samples of tramadol to every geriatric ward in Ohio? The same system that pays doctors bonuses for prescribing more meds? This isn’t a clinical guideline - it’s PR. The ‘alternatives’ list? A PR stunt to make Big Pharma look woke. CBT-I? Who’s going to pay for that? Medicare won’t cover it. So the elderly get the pills, and the corporations get the cash. You think this is about safety? It’s about liability. They don’t want lawsuits. They don’t care about your grandma’s balance. They care about their quarterly earnings.

And don’t even get me started on the ‘pharmacist-led reviews.’ You think those folks are working for the patient? They’re employees of hospital systems that bill $1200 per med review. The real cost? $40 in time. The rest? Profit margin. This isn’t care. It’s a tax on vulnerability.

And the ‘AI alerts’? They’re just going to get better at hiding the real problem: the fact that 80% of elderly prescriptions are written by doctors who’ve never taken a single geriatrics course. The system isn’t broken. It’s designed this way. You’re just being sold a Band-Aid on a severed limb.

Scott van Haastrecht

Scott van Haastrecht

7 December 2025

Everyone’s acting like this is some groundbreaking revelation. Newsflash: we’ve known this since the 90s. The Beers Criteria has been around for 30 years. The problem isn’t the list - it’s the people. Doctors are lazy. Hospitals are understaffed. Families are clueless. And now we’re pretending that slapping an alert in Epic is going to fix it? Please. I’ve seen ER docs ignore 12 warnings in a row because they’re rushing to discharge someone before shift change. The system doesn’t need more lists. It needs consequences. Fire the doctors who keep prescribing benzos to 80-year-olds. Audit every prescription over 70. Make it illegal to prescribe anticholinergics without a geriatric consult. Stop pretending this is a ‘guideline’ issue. It’s a culture of negligence. And no amount of CBT-I or ‘alternatives’ is going to fix that. You want change? Punish the people who keep doing harm. Not ‘educate’ them. Punish them. Then maybe we’ll see results.

Chase Brittingham

Chase Brittingham

8 December 2025

I just want to say thank you for writing this. My dad was on 11 meds when he got hospitalized last year - half of them he didn’t even know he was taking. We didn’t realize it until his pharmacist sat down with us and said, ‘You know, this one was for a UTI he had in 2019.’ I cried. Not because I was mad - because I felt guilty. We trusted the system. We thought ‘prescribed’ meant ‘necessary.’

I’m not a doctor. I’m not a pharmacist. But I brought every pill bottle to every appointment after that. We cut down to 5. He sleeps better. He walks without the cane. He laughs again.

I know it’s not easy. I know hospitals are overwhelmed. But if you’re reading this and you have an elderly parent or grandparent - please, just ask. Just one question: ‘Is this still needed?’ That’s all it takes to start changing things. And if your doctor doesn’t know the Beers Criteria? Print it out. Hand it to them. It’s free. It’s public. It’s right there.

We don’t need a revolution. We just need to care enough to ask.

Bill Wolfe

Bill Wolfe

9 December 2025

Let’s be real - the Beers Criteria is just the latest in a long line of medical virtue signaling. You want to know what’s really dangerous for the elderly? The cult of ‘de-prescribing’ that’s been pushed by overeducated, underworked geriatricians who think they know what’s best better than the patients themselves. Who says a 78-year-old can’t take a little lorazepam to sleep? Maybe they’ve tried CBT-I and it didn’t work. Maybe they’ve had insomnia for 20 years and this is the only thing that lets them rest. Why is their autonomy suddenly up for debate? Why is it assumed that every drug is a poison unless proven otherwise? The real danger isn’t polypharmacy - it’s paternalism. The medical elite telling elderly people they’re too fragile to make their own choices. You want to ‘protect’ them? Then let them choose. If they want to take the sleeping pill, let them. If they want to risk a fall for peace at night - that’s their life. Not yours. Not the AGS’s. Not Epic’s. The Beers Criteria isn’t safety. It’s control disguised as compassion. And it’s condescending.

Also, non-drug alternatives? Great. But they’re not always accessible. Not everyone lives near a physical therapist who takes Medicare. Not everyone can afford 12 sessions of CBT-I. So now we’re punishing people for being poor? Brilliant.

Let the elderly decide. Let them take their pills. Let them live their lives. Stop treating them like children who need to be ‘saved’ from themselves.

Ollie Newland

Ollie Newland

10 December 2025

From a clinical pharmacy standpoint, the real bottleneck isn’t the Beers Criteria - it’s the lack of longitudinal medication reconciliation. Most hospitals do it at admission, but that’s reactive, not proactive. What we need is a continuous, structured review cycle - quarterly, at minimum - tied to primary care visits. The AGS Alternatives List is a step forward, but without standardized implementation, it’s just a PDF on a server. The key is integration: EHR alerts need to trigger not just at prescribing, but at refill, at lab result anomalies (like hyponatremia after tramadol + hydrochlorothiazide), and at discharge. We also need to codify the ‘deprescribing’ process into clinical pathways, not leave it to individual initiative. And yes - geriatric pharmacists are non-negotiable. One FTE per 20,000 ED visits? That’s the bare minimum. The ROI is clear: one avoided readmission pays for three pharmacists. The problem isn’t evidence. It’s workflow design. We’re trying to solve a systems problem with individual education. It’s not working. We need process, not pamphlets.

Rebecca Braatz

Rebecca Braatz

12 December 2025

YOU CAN DO THIS. Seriously. If you’re reading this and you’re worried about your parent’s meds - you’re already doing better than 90% of families. Don’t wait for the system to fix itself. Grab the pill bottles. Write down every single thing - even the gummy vitamins. Go to the pharmacy and ask the pharmacist to do a med review. They’ll do it for free. Then go to your doctor and say, ‘I want to cut three of these.’ Don’t ask permission. Ask for a plan. You’re not being difficult. You’re being a guardian. I’ve seen people go from confused and falling to sharp and walking their dogs again - just by asking those four questions. It’s not magic. It’s courage. And you’ve got it. Now go do it. Your loved one deserves it. And so do you.

Michael Feldstein

Michael Feldstein

13 December 2025

Everyone’s so excited about the ‘alternatives’ list. But here’s the thing nobody’s saying: what if the elderly don’t want alternatives? What if they like their little blue pill? What if it’s the only thing that makes them feel human? You think CBT-I is better? Maybe. But it’s also exhausting. It’s work. It’s therapy. It’s accountability. And for someone who’s already tired, lonely, and in pain - sometimes a pill is the only comfort left. You’re not helping by taking it away. You’re just replacing one kind of suffering with another. And who gets to decide what’s ‘better’? The doctor? The pharmacist? The algorithm? Not the person living it. This isn’t safety. It’s moral superiority wrapped in clinical jargon. Let people choose their suffering. At least then it’s theirs.

jagdish kumar

jagdish kumar

15 December 2025

Medicine is the new religion. The pills are the sacraments. The doctors, the priests. The Beers Criteria? Just another holy text. But the faithful still worship the old gods. The altar is full of anticholinergics. The incense is NSAIDs. The communion wine? Benzodiazepines. And the congregation? The elderly, silent, nodding. They don’t ask. They don’t question. They swallow. And the priests say, ‘Amen.’

Benjamin Sedler

Benjamin Sedler

16 December 2025

Okay, but what if the real problem is that we’re living too long? Like, maybe the whole system is built for people who die at 70, and now we’re forcing it to handle 85-year-olds with 12 chronic conditions? Maybe we’re just putting Band-Aids on a dying system because we’re too scared to talk about end-of-life care? Everyone’s focused on ‘fixing’ the meds, but no one’s asking why we’re keeping people alive with 10 pills and no joy. What if the real solution isn’t safer drugs - but better deaths? I’m not saying give up. I’m saying maybe we need to stop treating aging like a medical failure. Maybe the problem isn’t polypharmacy - it’s that we’ve turned the last decade of life into a pharmacological battlefield instead of a time to be held, listened to, and loved. The pills are just the symptom. The disease is our fear of mortality.

Jessica Baydowicz

Jessica Baydowicz

17 December 2025

I just want to say - I used to think my mom was just getting ‘forgetful.’ Turns out, half her meds were making her confused. We cut three. She remembered my name again. She started baking pies. She hugged me. That’s not a win for medicine. That’s a win for asking. If you’re reading this and you’re scared to ask your doctor - I get it. I was too. But you owe it to them - and to yourself - to try. Just one question. That’s all it takes. You’ve got this. And you’re not alone.

val kendra

val kendra

18 December 2025

My grandma took 17 pills. We cut it to 6. She stopped falling. She started dancing in the kitchen. No fancy tech. No AI. Just us showing up with the bottle and asking ‘why?’
It’s not rocket science. It’s love.

George Graham

George Graham

18 December 2025

I’m from a rural town in Nebraska. We don’t have geriatric pharmacists. We don’t have AI alerts. We have one overworked PCP who sees 50 patients a day. I’ve watched my neighbors get prescribed the same benzos their parents took in the 80s. But here’s what I’ve learned - it’s not about the system. It’s about the person next to you. Last week, I sat with Mrs. Thompson and sorted her meds. She didn’t know she was still taking a blood pressure pill after her stroke. We called her daughter. We called the pharmacy. We stopped it. She smiled. Said she felt ‘lighter.’

You don’t need a hospital to change this. You just need to care enough to show up. Bring the bottles. Ask the questions. Sit with them. That’s the real Beers Criteria. Right there. In the kitchen. With the coffee.

And yeah - I’m a retired nurse. I’ve seen it all. But this? This is the stuff that matters.

Chase Brittingham

Chase Brittingham

20 December 2025

Just wanted to reply to @val_kendra - you’re so right. It’s not about the tech or the lists. It’s about showing up. My mom’s pharmacist said the same thing: ‘Bring the bottles. Don’t bring a list. Bring the bottles.’ We did. Found three she’d forgotten about. One was for a UTI from 2017. She hadn’t had one since. We stopped it. She didn’t even notice - until she started sleeping through the night. That’s the real win. Not the algorithm. Not the guideline. Just someone who cared enough to look.

And @jagdish_kumar - your comment about religion? That hit me. Maybe we’ve turned medicine into a ritual. We hand out pills like blessings. We don’t question. We just accept. But maybe - just maybe - the real miracle isn’t the drug. It’s the moment someone asks, ‘Why?’

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