Arava Side Effects: What You Need to Know Before Taking It

When you’re prescribed Arava, a disease-modifying antirheumatic drug used to treat rheumatoid arthritis. Also known as leflunomide, it works by calming down an overactive immune system that’s attacking your joints. But like all strong medications, it doesn’t come without risks. Many people take Arava without issues, but others face side effects that can be serious—especially if they’re not monitored closely.

One of the biggest concerns with Arava, a potent immunosuppressant. Also known as leflunomide, it can weaken your body’s ability to fight infection. That means colds can turn into pneumonia, and minor cuts might get infected faster. Liver damage is another real risk—some patients have needed hospitalization because their enzymes spiked. That’s why doctors require regular blood tests, especially in the first six months. You might also notice diarrhea, hair thinning, or high blood pressure. These aren’t rare. In fact, up to 20% of users report them. If you’re on other meds like methotrexate or NSAIDs, the chance of interactions goes up. And if you’re planning to get pregnant, Arava can cause birth defects. You need a special washout procedure before trying to conceive.

What’s often overlooked is how long Arava stays in your system. Unlike most drugs that leave your body in days, this one lingers for months—even after you stop taking it. That’s why doctors give you a cholestyramine protocol to speed up removal if needed. It’s not just about the immediate side effects; it’s about long-term safety. People who’ve taken it for years need ongoing checks for liver, kidney, and blood health. This isn’t a drug you start and forget. It’s a commitment.

The posts below cover real-world experiences and clinical insights on Arava and similar treatments. You’ll find comparisons with other rheumatoid arthritis drugs, stories from people who managed side effects, and clear advice on when to push back on your doctor or seek a second opinion. Whether you’re just starting Arava or have been on it for a while, these guides give you the facts you won’t get in a one-page pamphlet.