Flutamide: Uses, Side Effects, Dosing, and Safety

Flutamide is an oral antiandrogen used mostly to treat prostate cancer and, in some cases, severe hirsutism in women. It works by blocking testosterone from binding to its receptor, which slows growth of androgen-driven tissues. Doctors prescribe it when other hormonal options are not enough or not suitable.

Typical dosing for adults with prostate cancer is 250 mg taken three times daily, though exact regimens vary and your doctor sets the dose. Women who take flutamide for hirsutism usually use lower doses and are monitored closely. Never change dose or stop suddenly without a clinician’s advice.

Key side effects and warnings

The biggest safety concern with flutamide is liver toxicity. Patients can develop elevated liver enzymes and, rarely, liver failure. For that reason doctors run liver tests before starting treatment and periodically afterwards — usually every 2 to 4 weeks at first, then less often if levels stay normal.

Other common side effects include hot flashes, decreased libido, impotence, diarrhea, and nausea. Women may experience menstrual changes. If you notice jaundice, dark urine, severe fatigue, or abdominal pain, stop the drug and contact medical help right away.

Interactions, monitoring, and who should avoid it

Flutamide can interact with other drugs that affect the liver or that change hormone balance. Tell your clinician about all prescription meds, over-the-counter drugs, and supplements you take. Avoid alcohol or keep it very limited while on flutamide because it raises liver risk.

People with known liver disease, active hepatitis, or unexplained liver enzyme elevations should not use flutamide. It's also not recommended during pregnancy; women who can get pregnant must use effective contraception and avoid exposure to the drug.

If you are prescribed flutamide, expect regular blood tests: liver panels, and sometimes blood counts and PSA for prostate cancer patients. Keep a medication list and report any new symptoms quickly. Carry a reminder that you are on flutamide in case of emergency care.

Alternatives to flutamide include other antiandrogens like bicalutamide or newer hormonal therapies; each has its own safety profile and benefits. Decisions depend on cancer stage, other health problems, and patient preference. Ask your oncologist or endocrinologist to explain the options and why one drug fits your situation.

Buying flutamide online can be risky. Only use licensed pharmacies with a valid prescription and clear contact info. Avoid sites that sell without prescription or offer suspiciously low prices — counterfeit or unsafe products are common risks.

Questions to ask your clinician: Why this drug for me? How often will you test my liver? What signs should make me stop the drug? How does it compare to other antiandrogens? Keeping these points clear helps you stay safe and get the best results.

Most people notice symptom changes for prostate cancer treatment through PSA changes rather than feeling different. You may feel hot flashes and tiredness within days or weeks. Liver tests commonly show small enzyme rises; many are temporary but some need stopping the drug. Costs vary: generic flutamide is cheaper than brand drugs, but insurance coverage differs. Always check with your pharmacy and compare prices regularly.