Differin Comparison: How It Stacks Up Against Other Acne Treatments

When you’re fighting acne, Differin, a topical retinoid containing adapalene, used to treat mild to moderate acne by unclogging pores and reducing inflammation. Also known as adapalene gel, it’s one of the few acne treatments available over the counter in many countries, making it a go-to for people who want results without a prescription. But is it better than the alternatives? That’s the question most people ask after seeing their first tube sit on the shelf for weeks.

Differin isn’t the only player in this game. tretinoin, a stronger prescription retinoid that speeds up skin cell turnover and reduces acne scars over time has been the gold standard for decades. But it often causes redness, peeling, and irritation—especially at first. Differin? It’s gentler. Studies show it works nearly as well as tretinoin for most people, with fewer side effects. Then there’s benzoyl peroxide, an antibacterial agent that kills acne-causing bacteria and reduces oil buildup. It works fast, but it bleaches towels and can dry out your skin. Differin doesn’t bleach anything, and it targets the root cause—clogged pores—not just the bacteria.

People who switch from benzoyl peroxide to Differin often notice fewer breakouts over time, not just clearer skin in the short term. That’s because Differin changes how your skin behaves. It doesn’t just treat pimples—it prevents them from forming. Compared to salicylic acid, which only exfoliates the surface, Differin works deeper. And unlike oral antibiotics, which can lead to resistance, Differin doesn’t make your skin immune to its effects.

But here’s the catch: Differin doesn’t work overnight. Most people see results after 8 to 12 weeks. If you’re looking for a quick fix, you’ll be disappointed. But if you’re in it for the long haul, it’s one of the most reliable tools you can use. And unlike some prescription options, you can buy it online, at the pharmacy, or even at your local supermarket—no doctor’s note needed.

What you’ll find below is a collection of real, practical comparisons. We’ve looked at how Differin stacks up against tretinoin, adapalene generics, benzoyl peroxide, and even natural alternatives like tea tree oil. We’ve checked side effects, cost, how long results last, and what happens when you stop using it. No fluff. No marketing. Just what works, what doesn’t, and why.