Top Avana (Dapoxetine & Avanafil) vs. Alternatives: Full Comparison Guide

• Oct, 4 2025
• 5

Key Takeaways

• Top Avana uniquely combines a premature ejaculation drug (dapoxetine) with an erectile dysfunction drug (avanafil) in one tablet.
• Onset of action for avanafil is as fast as 15 minutes, while dapoxetine works within 1-2 hours.
• Alternatives such as sildenafil, tadalafil, and vardenafil address erectile dysfunction only; Priligy focuses solely on premature ejaculation.
• Choose based on your primary concern, timing needs, side‑effect profile, and any contraindications.
• Always discuss with a healthcare professional before starting any prescription sexual‑health medication.

When you’re hunting for a pill that tackles both erectile dysfunction (ED) and premature ejaculation (PE) at the same time, Top Avana is the brand that promises a one‑stop solution. It pairs dapoxetine for PE with avanafil for ED, aiming to simplify the regimen for men dealing with both issues. Below we break down how it works, compare it with the most common alternatives, and help you decide which option fits your lifestyle.

What Is Top Avana?

Top Avana is a combination tablet that contains two active ingredients: 60mg of avanafil (a phosphodiesterase‑5 inhibitor) and 30mg of dapoxetine (a selective serotonin reuptake inhibitor). It was developed for men who experience both ED and PE and want a single prescription instead of juggling two separate pills. The tablet is taken on an as‑needed basis, typically 30 minutes before sexual activity, and its fast‑acting avanafil component can start working in as little as 15 minutes. Dapoxetine, on the other hand, reaches peak plasma levels in about 1-2 hours, giving you a window of improved control for the entire sexual encounter.

How Dapoxetine Works

Dapoxetine belongs to the class of short‑acting selective serotonin reuptake inhibitors (SSRIs). By briefly increasing serotonin levels in the central nervous system, it lengthens the time it takes to ejaculate without the long‑term side‑effects typical of daily SSRIs. The recommended dose for PE is 30mg taken 1-2 hours before sex, and it can be increased to 60mg if tolerated. Common side effects include nausea, dizziness, and mild insomnia, but they usually subside after a few days of use.

How Avanafil Works

Avanafil is a newer generation phosphodiesterase‑5 (PDE5) inhibitor. It blocks the PDE5 enzyme in the penile tissue, allowing cyclic guanosine monophosphate (cGMP) to accumulate and sustain an erection when sexual stimulation occurs. Its rapid absorption gives it one of the quickest onsets among PDE5 inhibitors-often within 15 minutes-making it a good choice for spontaneous activity. The typical dose range is 50-200mg, taken as needed. Side effects are usually mild and may include headache, flushing, or nasal congestion.

Common Erectile Dysfunction Alternatives

• Sildenafil (brand name Viagra) - Onset 30-60 minutes, duration up to 5 hours. Doses: 25-100mg.
• Tadalafil (brand name Cialis) - Onset 30 minutes, duration up to 36 hours. Doses: 5-20mg.
• Vardenafil (brand name Levitra) - Onset 30 minutes, duration up to 5 hours. Doses: 5-20mg.
• Stendra - The brand name for avanafil when sold alone. Onset 15 minutes, duration up to 6 hours. Doses: 50-200mg.

Premature Ejaculation‑Only Alternatives

• Priligy - The commercial name for dapoxetine taken alone. Same dosing schedule as dapoxetine in TopAvana.
• Topical anesthetic sprays (e.g., lidocaine‑prilocaine) - Provide temporary desensitization rather than systemic medication.
• Behavioral techniques (stop‑start, squeeze) - Non‑pharmacologic approaches used alongside or instead of medication.

Side‑Effect Profile Comparison

All sexual‑health drugs share some overlapping side effects, but the combination in Top Avana introduces a unique mix. Below is a concise table that lines up the most relevant attributes of each option.

When Top Avana Is the Right Choice

If you consistently experience both ED and PE, the combined pill saves you from taking two separate prescriptions. It’s also ideal when you want a fast‑acting ED component (avanafil) that won’t force you to plan several hours ahead. However, the trade‑off is that you’re exposed to the side‑effects of both drugs simultaneously, which can be a deal‑breaker for men sensitive to nausea or dizziness.

When to Opt for Separate Medications

Many men only need to address one issue at a time. If your main concern is ED and PE is occasional, a single PDE5 inhibitor (sildenafil, tadalafil, or avanafil alone) keeps the medication load lower. Conversely, if you only need PE control, dapoxetine (Priligy) or a topical spray will avoid unnecessary cardiovascular exposure that comes with PDE5 inhibitors.

Decision Checklist

1. Identify your primary symptom: ED, PE, or both.
2. Check for contraindications: nitrate use, severe heart disease, uncontrolled hypertension.
3. Consider timing needs: spontaneous activity favors avanafil‑based options.
4. Review side‑effect tolerance: nausea (dapoxetine) vs. headache (PDE5 inhibitors).
5. Assess cost and insurance coverage: combo pills may be pricier than single agents.

Safety Tips and Potential Risks

All prescription sexual‑health drugs share some common cautions. Never combine a PDE5 inhibitor with nitrates (e.g., nitroglycerin) as it can cause dangerous blood‑pressure drops. If you have a history of heart rhythm disorders, discuss the cardiac safety of dapoxetine‑containing combos with your doctor. Alcohol can amplify dizziness and lower blood pressure, so limit intake around dosing. Finally, store tablets at room temperature and keep them out of reach of children.

Next Steps

1. Book an appointment with your GP or a urologist. 2. Bring a list of current medications (including over‑the‑counter supplements). 3. Discuss whether a combination product like Top Avana aligns with your lifestyle. 4. If prescribed, compare pharmacy prices; some online dispensaries may offer bulk discounts. 5. Start with the lowest recommended dose and monitor how you feel before adjusting.